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Small cleaved cells are a distinctive type of cell that appears in certain types of lymphoma. When used to uniquely identify a type of lymphoma, they are usually categorized as follicular () or diffuse () . The "small cleaved cells" are usually centrocytes that express B-cell markers such as CD20. The disease is strongly correlated with the genetic translocation t(14;18), which results in juxtaposition of the bcl-2 proto-oncogene with the heavy chain JH locus, and thus in overexpression of bcl-2. Bcl-2 is a well known anti-apoptotic gene, and thus its overexpression results in the "failure to die" motif of cancer seen in follicular lymphoma. Follicular lymphoma must be carefully monitored, as it often progresses into a more aggressive "Diffuse Large B-Cell Lymphoma." ==External links== * * * * 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Small cleaved cells」の詳細全文を読む スポンサード リンク
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